Reiver Sanmartin had another strong outing in a Chattanooga Lookouts win, Jose Garcia helped out with a go-ahead RBI in the 8th of that victory, and Sam Hellinger struck out seven batters out of Dayton’s bullpen.
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The Louisville Bats lost 4-3. Box Score
- Mike Freeman went 2-4 with a run and an RBI.
- Nicky Delmonico went 1-3 with a walk and an RBI.
- Dwight Smith Jr. went 1-4.
- Beau Taylor went 1-3 with a walk and a run scored.
- R.J. Alaniz threw 1.2 perfect innings with 3 strikeouts.
- Phillip Diehl threw a perfect inning.
The Chattanooga Lookouts won 4-1. Box Score
- Jose Garcia went 1-3 with a double, walk, and an RBI.
- Wilson Garcia went 2-4 with an RBI.
- TJ Hopkins went 2-4 with a run scored.
- Jay Schuyler went 1-4 with a run.
- Robbie Tenerowicz went 1-3.
- Reiver Sanmartin threw 6.0 shutout innings on 3 hits, a walk, and he had 8 strikeouts.
- Ryan Olson threw 1.1 shutout innings with a strikeout.
- Alexis Diaz threw a hitless inning with a walk and a strikeout.
The Dayton Dragons lost 5-0. Box Score
- Juan Martinez went 1-3 with a walk.
- Miguel Hernandez went 1-3.
- Mariel Bautista went 1-3.
- Jacob Hurtubise went 1-1 as a late game replacement.
- Lyon Richardson was charged with 4 unearned runs in 3.0 innings on 5 hits and 2 walks with 4 strikeouts.
- Sam Hellinger threw 3.0 shutout innings with 7 strikeouts.
- Jake Gilbert allowed a run in 2.0 innings with a walk and a strikeout.
The Daytona Tortugas lost 5-4. Box Score
- Tyler Callihan went 2-4 with a run scored.
- Austin Hendrick went 0-2 with 2 walks and a run scored.
- Allan Cerda went 1-4 with a 2-run home run (4).
- Michel Triana went 0-2 with 2 walks.
- Danny Lantigua went 2-4 with a solo home run (2).
- Garrett Wolforth went 1-4.
- Case Williams allowed a run in 5.0 innings on 2 hits and 3 walks.
- Tanner Cooper threw 3.0 shutout innings with 3 strikeouts.
5/22 Game Preview
| Team | Record | Time (ET) | Probable | Box Score | Listen | Watch |
| Louisville | 4-11 | 7:15pm | Shipley | Here | Here | Here |
| Chattanooga | 10-6 | 7:05pm | Greene | Here | Here | Here |
| Dayton | 10-6 | 7:05pm | Salazar | Here | Here | Here |
| Daytona | 8-8 | 7:05pm | Proctor | Here | Here | N/A |